About Phosphoinositide 3-kinase regulatory subunit 5
Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5) is a protein
from Homo sapiens identified by UniProt accession
Q8WYR1, 880 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Phosphoinositide 3-kinase regulatory subunit 5 |
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| UniProt accession | Q8WYR1 |
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| Gene | PIK3R5 |
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| Organism | Homo sapiens |
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| Length | 880 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (166)
Diseases linked to this target (Open Targets).
- Spinocerebellar ataxia with axonal neuropathy type 2 · score 0.48
- breast cancer · score 0.36
- glioblastoma multiforme · score 0.30
- Thyroid preparation use measurement · score 0.30
- autoimmune thyroid disease · score 0.30
- hypothyroidism · score 0.30
- eosinophil count · score 0.29
- endometrial cancer · score 0.28
- infection · score 0.28
- head and neck squamous cell carcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WYR1-F1 | alphafold | PREDICTED | 70.80 | — |
Amino-acid sequence (880 residues)
MQPGATTCTE DRIQHALERC LHGLSLSRRS TSWSAGLCLN CWSLQELVSR DPGHFLILLE QILQKTREVQ EKGTYDLLTP LALLFYSTVL CTPHFPPDSD LLLKAASTYH RFLTWPVPYC SICQELLTFI DAELKAPGIS YQRLVRAEQG LPIRSHRSST VTVLLLNPVE VQAEFLAVAN KLSTPGHSPH SAYTTLLLHA FQATFGAHCD VPGLHCRLQA KTLAELEDIF TETAEAQELA SGIGDAAEAR RWLRTKLQAV GEKAGFPGVL DTAKPGKLHT IPIPVARCYT YSWSQDSFDI LQEILLKEQE LLQPGILGDD EEEEEEEEEV EEDLETDGHC AERDSLLSTS SLASHDSTLS LASSQASGPA LSRHLLTSFV SGLSDGMDSG YVEDSEESSS EWPWRRGSQE RRGHRRPGQK FIRIYKLFKS TSQLVLRRDS RSLEGSSDTA LPLRRAGSLC SPLDEPVSPP SRAQRSRSLP QPKLGTQLPS WLLAPASRPQ RRRPFLSGDE DPKASTLRVV VFGSDRISGK VARAYSNLRR LENNRPLLTR FFKLQFFYVP VKRSHGTSPG ACPPPRSQTP SPPTDSPRHA SPGELGTTPW EESTNDISHY LGMLDPWYER NVLGLMHLPP EVLCQQSLKA EAQALEGSPT QLPILADMLL YYCRFAARPV LLQVYQTELT FITGEKTTEI FIHSLELGHS AATRAIKASG PGSKRLGIDG DREAVPLTLQ IIYSKGAISG RSRWSNLEKV CTSVNLNKAC RKQEELDSSM EALTLNLTEV VKRQNSKSKK GFNQISTSQI KVDKVQIIGS NSCPFAVCLD QDERKILQSV VRCEVSPCYK PEKSDLSSPP QTPPDLPAQA APDLCSLLCL PIMTFSGALP
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