About Transmembrane O-methyltransferase
Transmembrane O-methyltransferase (TOMT) is a protein
from Homo sapiens identified by UniProt accession
Q8WZ04, 291 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Transmembrane O-methyltransferase |
|---|
| UniProt accession | Q8WZ04 |
|---|
| Gene | TOMT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 291 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- autosomal recessive nonsyndromic hearing loss 63 · score 0.68
- deafness · score 0.47
- hearing loss · score 0.37
- Asperger syndrome · score 0.08
- autism · score 0.07
- age-related macular degeneration · score 0.07
- X-linked retinal dysplasia · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- attention deficit hyperactivity disorder · score 0.06
- retinitis pigmentosa · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WZ04-F1 | alphafold | PREDICTED | 90.37 | — |
Amino-acid sequence (291 residues)
MGTPWRKRKG IAGPGLPDLS CALVLQPRAQ VGTMSPAIAL AFLPLVVTLL VRYRHYFRLL VRTVLLRSLR DCLSGLRIEE RAFSYVLTHA LPGDPGHILT TLDHWSSRCE YLSHMGPVKG QILMRLVEEK APACVLELGT YCGYSTLLIA RALPPGGRLL TVERDPRTAA VAEKLIRLAG FDEHMVELIV GSSEDVIPCL RTQYQLSRAD LVLLAHRPRC YLRDLQLLEA HALLPAGATV LADHVLFPGA PRFLQYAKSC GRYRCRLHHT GLPDFPAIKD GIAQLTYAGP G
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