About Barttin
Barttin (BSND) is a protein
from Homo sapiens identified by UniProt accession
Q8WZ55, 320 residues long.
MolForge cross-references it against 0 known binders and
163 disease associations.
Target properties
| Protein name | Barttin |
|---|
| UniProt accession | Q8WZ55 |
|---|
| Gene | BSND |
|---|
| Organism | Homo sapiens |
|---|
| Length | 320 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (163)
Diseases linked to this target (Open Targets).
- Bartter disease type 4A · score 0.83
- Bartter syndrome · score 0.62
- hearing loss, autosomal recessive · score 0.43
- Bartter syndrome type 4 · score 0.38
- hearing loss · score 0.37
- Hearing impairment · score 0.37
- deafness · score 0.26
- Hypercholesterolemia · score 0.23
- coronary artery disease · score 0.20
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WZ55-F1 | alphafold | PREDICTED | 53.70 | — |
Amino-acid sequence (320 residues)
MADEKTFRIG FIVLGLFLLA LGTFLMSHDR PQVYGTFYAM GSVMVIGGII WSMCQCYPKI TFVPADSDFQ GILSPKAMGL LENGLAAEMK SPSPQPPYVR LWEEAAYDQS LPDFSHIQMK VMSYSEDHRS LLAPEMGQPK LGTSDGGEGG PGDVQAWMEA AVVIHKGSDE SEGERRLTQS WPGPLACPQG PAPLASFQDD LDMDSSEGSS PNASPHDREE ACSPQQEPQG CRCPLDRFQD FALIDAPTLE DEPQEGQQWE IALPNNWQRY PRTKVEEKEA SDTGGEEPEK EEEDLYYGLP DGAGDLLPDK ELGFEPDTQG
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