About Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2) is a protein
from Homo sapiens identified by UniProt accession
Q8WZ64, 1704 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 |
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| UniProt accession | Q8WZ64 |
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| Gene | ARAP2 |
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| Organism | Homo sapiens |
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| Length | 1704 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- influenza A (H1N1) · score 0.36
- metabolic syndrome · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.33
- breast carcinoma · score 0.31
- estrogen-receptor negative breast cancer · score 0.31
- response to antineoplastic agent · score 0.31
- survival time · score 0.31
- gut microbiome measurement · score 0.30
- diastolic blood pressure · score 0.28
- skin aging measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WZ64-F1 | alphafold | PREDICTED | 66.79 | — |
Amino-acid sequence (1704 residues)
MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG ISPTGHRRRI LKQLQIILSK MQDIPIYANV HKTKKNDDPS KDYHVPSSDQ NICIELSNSG SVQTSSPPQL ETVRKNLEDS DASVERSQYP QSDDKLSPPK RDFPTAEEPH LNLGSLNDSL FGSDNIKIES LITKKTVDHT VEEQQTEKVK LITENLSKLP NADSECLSFV GCSTSGTNSG NGTNGLLEGS PPSPFFKFQG EMIVNDLYVP SSPILAPVRS RSKLVSRPSR SFLLRHRPVP EIPGSTKGVS GSYFRERRNV ATSTEKSVAW QNSNEENSSS IFPYGETFLF QRLENSKKRS IKNEFLTQGE ALKGEAATAT NSFIIKSSIY DNRKEKISED KVEDIWIPRE DKNNFLIDTA SESEYSTVEE CFQSLRRKNS KASKSRTQKA LILDSVNRHS YPLSSTSGNA DSSAVSSQAI SPYACFYGAS AKKVKSGWLD KLSPQGKRMF QKRWVKFDGL SISYYNNEKE MYSKGIIPLS AISTVRVQGD NKFEVVTTQR TFVFRVEKEE ERNDWISILL NALKSQSLTS QSQAVVTPEK CGYLELRGYK AKIFTVLSGN SVWLCKNEQD FKSGLGITII PMNVANVKQV DRTVKQSFEI ITPYRSFSFT AETEKEKQDW IEAVQQSIAE TLSDYEVAEK IWFNESNRSC ADCKAPDPDW ASINLCVVIC KKCAGQHRSL GPKDSKVRSL KMDASIWSNE LIELFIVIGN KRANDFWAGN LQKDEELHMD SPVEKRKNFI TQKYKEGKFR KTLLASLTKE ELNKALCAAV VKPDVLETMA LLFSGADVMC ATGDPVHSTP YLLAKKAGQS LQMEFLYHNK FSDFPQHDIH SEGVLSQESS QSTFLCDFLY QAPSAASKLS SEKKLLEETN KKWCVLEGGF LSYYENDKST TPNGTININE VICLAIHKED FYLNTGPIFI FEIYLPSERV FLFGAETSQA QRKWTEAIAK HFVPLFAENL TEADYDLIGQ LFYKDCHALD QWRKGWFAMD KSSLHFCLQM QEVQGDRMHL RRLQELTIST MVQNGEKLDV LLLVEKGRTL YIHGHTKLDF TVWHTAIEKA AGTDGNALQD QQLSKNDVPI IVNSCIAFVT QYGLGCKYIY QKNGDPLHIS ELLESFKKDA RSFKLRAGKH QLEDVTAVLK SFLSDIDDAL LTKELYPYWI SALDTQDDKE RIKKYGAFIR SLPGVNRATL AAIIEHLYRV QKCSEINHMN AHNLALVFSS CLFQTKGQTS EEVNVIEDLI NNYVEIFEVK EDQVKQMDIE NSFITKWKDT QVSQAGDLLI EVYVERKEPD CSIIIRISPV MEAEELTNDI LAIKNIIPTK GDIWATFEVI ENEELERPLH YKENVLEQVL RWSSLAEPGS AYLVVKRFLT ADTIKHCSDR STLGSIKEGI LKIKEEPSKI LSGNKFQDRY FVLRDGFLFL YKDVKSSKHD KMFSLSSMKF YRGVKKKMKP PTSWGLTAYS EKHHWHLCCD SSRTQTEWMT SIFIAQHEYD IWPPAGKERK RSITKNPKIG GLPLIPIQHE GNATLARKNI ESARAELERL RLSEKCDKES VDSSLKERAS MVAHCLEHKD DKLRNRPRKH RSFNCLEDTE PEAPLGQPKG HKGLKTLRKT EDRNSKATLD SDHKLPSRVI EELNVVLQRS RTLPKELQDE QILK
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