About Cortactin-binding protein 2
Cortactin-binding protein 2 (CTTNBP2) is a protein
from Homo sapiens identified by UniProt accession
Q8WZ74, 1663 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Cortactin-binding protein 2 |
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| UniProt accession | Q8WZ74 |
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| Gene | CTTNBP2 |
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| Organism | Homo sapiens |
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| Length | 1663 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.45
- smoking status measurement · score 0.43
- smoking initiation · score 0.42
- unipolar depression · score 0.42
- type 2 diabetes mellitus · score 0.41
- self reported educational attainment · score 0.41
- depressive symptom measurement · score 0.40
- neuroimaging measurement · score 0.40
- wellbeing measurement · score 0.40
- brain measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8WZ74-F1 | alphafold | PREDICTED | 58.01 | — |
Amino-acid sequence (1663 residues)
MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK KPVCTNPLSI LEAVMAHCKK MQERMSAQLA AAESRQKKLE MEKLQLQALE QEHKKLAARL EEERGKNKQV VLMLVKECKQ LSGKVIEEAQ KLEDVMAKLE EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ LRAKLNREEA HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT MARPGIDRQA SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP LPSNAAPPTA QTPGIAPQNS QAPPMHSLHS PCANTSLHPG LNPRIQAARF RFQGNANDPD QNGNTTQSPP SRDVSPTSRD NLVAKQLARN TVTQALSRFT SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG NPPPIPPKKP GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA CSDSSLVIPT TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLSAEAQV NAADKNGFTP LCAAAAQGHF ECVELLISYD ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT TDGWTPVHAA VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV HDVATDDCKH LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI RKQTSWDDFS KAVSQALTNH FQAISSDGWW SLEDVTCNNT TDSNIGLSAR SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK AEHITVLLSG PQEGCLSSVT YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL ALCLKHRQMA AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA KACLQGSDLL VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP CDPVCKIVDW ALSVWRQLNS CLARLGTPEA LLGPKYFLSC PVVPGHAQVT VKWMSKLWNG VIAPRVQEAI LSRASVKRQP GFGQTTAKRH PSQGQQAVVK AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS SYNTCNKKKG ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA DSRDDLRMFD SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS KTELGVSRVK SFLPVPRSKV TQCSQNTKRS SSSSNTRQIE INNNSKEVNW NLHKNEHLEK PNK
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