Deoxyribonuclease-2-beta (DNASE2B)

About Deoxyribonuclease-2-beta

Deoxyribonuclease-2-beta (DNASE2B) is a protein from Homo sapiens identified by UniProt accession Q8WZ79, 361 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Deoxyribonuclease-2-beta
UniProt accession	Q8WZ79
Gene	DNASE2B
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (108)

Diseases linked to this target (Open Targets).

neuroticism measurement · score 0.15
Total congenital cataract · score 0.08
metabolite measurement · score 0.08
Cataract-microcornea syndrome · score 0.06
granular corneal dystrophy type II · score 0.06
early-onset non-syndromic cataract · score 0.06
Posterior polar cataract · score 0.06
cataract · score 0.06
cataract 12 multiple types · score 0.05
Anterior polar cataract · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WZ79-F1	alphafold	PREDICTED	90.95	—

Amino-acid sequence (361 residues)

MKQKMMARLL RTSFALLFLG LFGVLGAATI SCRNEEGKAV DWFTFYKLPK RQNKESGETG LEYLYLDSTT RSWRKSEQLM NDTKSVLGRT LQQLYEAYAS KSNNTAYLIY NDGVPKPVNY SRKYGHTKGL LLWNRVQGFW LIHSIPQFPP IPEEGYDYPP TGRRNGQSGI CITFKYNQYE AIDSQLLVCN PNVYSCSIPA TFHQELIHMP QLCTRASSSE IPGRLLTTLQ SAQGQKFLHF AKSDSFLDDI FAAWMAQRLK THLLTETWQR KRQELPSNCS LPYHVYNIKA IKLSRHSYFS SYQDHAKWCI SQKGTKNRWT CIGDLNRSPH QAFRSGGFIC TQNWQIYQAF QGLVLYYESC K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards