CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4)

About CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (ST8SIA4) is a protein from Homo sapiens identified by UniProt accession Q92187, 359 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
UniProt accession	Q92187
Gene	ST8SIA4
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92187-F1	alphafold	PREDICTED	86.43	—

Amino-acid sequence (359 residues)

MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELSLSRSLVN SSDKIIRKAG SSIFQHNVEG WKINSSLVLE IRKNILRFLD AERDVSVVKS SFKPGDVIHY VLDRRRTLNI SHDLHSLLPE VSPMKNRRFK TCAVVGNSGI LLDSECGKEI DSHNFVIRCN LAPVVEFAAD VGTKSDFITM NPSVVQRAFG GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV NALILKNKLK VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK LTTGKCVKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards