DNA damage-binding protein 2 (DDB2)

About DNA damage-binding protein 2

DNA damage-binding protein 2 (DDB2) is a protein from Homo sapiens identified by UniProt accession Q92466, 427 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.

Target properties

Protein name	DNA damage-binding protein 2
UniProt accession	Q92466
Gene	DDB2
Organism	Homo sapiens
Length	427 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (244)

Diseases linked to this target (Open Targets).

xeroderma pigmentosum group E · score 0.79
Xeroderma pigmentosum complementation group E · score 0.56
xeroderma pigmentosum · score 0.42
hemangioblastoma · score 0.37
prostate carcinoma · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
skin basal cell carcinoma · score 0.37
head and neck squamous cell carcinoma · score 0.34
acute myeloid leukemia · score 0.33
squamous cell lung carcinoma · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92466-F1	alphafold	PREDICTED	83.59	—

Amino-acid sequence (427 residues)

MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS DCLWVGLAGP QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS YRILQKAAPF DRRATSLAWH PTHPSTVAVG SKGGDIMLWN FGIKDKPTFI KGIGAGGSIT GLKFNPLNTN QFYASSMEGT TRLQDFKGNI LRVFASSDTI NIWFCSLDVS ASSRMVVTGD NVGNVILLNM DGKELWNLRM HKKKVTHVAL NPCCDWFLAT ASVDQTVKIW DLRQVRGKAS FLYSLPHRHP VNAACFSPDG ARLLTTDQKS EIRVYSASQW DCPLGLIPHP HRHFQHLTPI KAAWHPRYNL IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF NPMGDTLASA MGYHILIWSQ EEARTRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards