Transcription factor AP-2-beta (TFAP2B)

About Transcription factor AP-2-beta

Transcription factor AP-2-beta (TFAP2B) is a protein from Homo sapiens identified by UniProt accession Q92481, 460 residues long. MolForge cross-references it against 0 known binders and 434 disease associations.

Target properties

Protein name	Transcription factor AP-2-beta
UniProt accession	Q92481
Gene	TFAP2B
Organism	Homo sapiens
Length	460 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (434)

Diseases linked to this target (Open Targets).

Char syndrome · score 0.80
patent ductus arteriosus 2 · score 0.61
body mass index · score 0.53
lean body mass · score 0.51
type 2 diabetes mellitus · score 0.50
body fat percentage · score 0.50
obesity · score 0.49
physical activity measurement · score 0.49
fat body mass · score 0.48
waist circumference · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92481-F1	alphafold	PREDICTED	66.05	—

Amino-acid sequence (460 residues)

MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP YSSAPPLSHT PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ PQQHPWGQRQ RQEVGSEAGS LLPQPRAALP QLSGLDPRRD YHSVRRPDVL LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ SVEDANNSGM NLLDQSVIKK VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL HSRKNMLLAT KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL ITHGFGAPAI CAALTALQNY LTEALKGMDK MFLNNTTTNR HTSGEGPGSK TGDKEEKHRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards