About Aquaporin-3
Aquaporin-3 (AQP3) is a protein
from Homo sapiens identified by UniProt accession
Q92482, 292 residues long.
MolForge cross-references it against 0 known binders and
412 disease associations.
Target properties
| Protein name | Aquaporin-3 |
|---|
| UniProt accession | Q92482 |
|---|
| Gene | AQP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 292 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (412)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- lung adenocarcinoma · score 0.25
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.11
- gonorrhea · score 0.11
- non-small cell lung carcinoma · score 0.09
- cancer · score 0.09
- osteosarcoma · score 0.08
- squamous cell carcinoma · score 0.08
- nail-patella syndrome · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92482-F1 | alphafold | PREDICTED | 93.78 | — |
Amino-acid sequence (292 residues)
MGRQKELVSR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR GTHGGFLTIN LAFGFAVTLG ILIAGQVSGA HLNPAVTFAM CFLAREPWIK LPIYTLAQTL GAFLGAGIVF GLYYDAIWHF ADNQLFVSGP NGTAGIFATY PSGHLDMING FFDQFIGTAS LIVCVLAIVD PYNNPVPRGL EAFTVGLVVL VIGTSMGFNS GYAVNPARDF GPRLFTALAG WGSAVFTTGQ HWWWVPIVSP LLGSIAGVFV YQLMIGCHLE QPPPSNEEEN VKLAHVKHKE QI
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