About Complement factor H-related protein 4
Complement factor H-related protein 4 (CFHR4) is a protein
from Homo sapiens identified by UniProt accession
Q92496, 578 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Complement factor H-related protein 4 |
|---|
| UniProt accession | Q92496 |
|---|
| Gene | CFHR4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 578 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.49
- age-related macular degeneration · score 0.45
- hemopexin measurement · score 0.30
- neurodegenerative disease · score 0.29
- complement factor H-related protein 4A measurement · score 0.27
- mean arterial pressure · score 0.21
- systolic blood pressure · score 0.21
- complement factor H-related protein 2 measurement · score 0.19
- sex hormone-binding globulin measurement · score 0.19
- coagulation factor measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92496-F1 | alphafold | PREDICTED | 87.56 | — |
Amino-acid sequence (578 residues)
MLLLINVILT LWVSCANGQE VKPCDFPEIQ HGGLYYKSLR RLYFPAAAGQ SYSYYCDQNF VTPSGSYWDY IHCTQDGWSP TVPCLRTCSK SDVEIENGFI SESSSIYILN EETQYNCKPG YATAEGNSSG SITCLQNGWS TQPICIKFCD MPVFENSRAK SNGMWFKLHD TLDYECYDGY ESSYGNTTDS IVCGEDGWSH LPTCYNSSEN CGPPPPISNG DTTSFPQKVY LPWSRVEYQC QSYYELQGSK YVTCSNGDWS EPPRCISMKP CEFPEIQHGH LYYENTRRPY FPVATGQSYS YYCDQNFVTP SGSYWDYIHC TQDGWLPTVP CLRTCSKSDI EIENGFISES SSIYILNKEI QYKCKPGYAT ADGNSSGSIT CLQNGWSAQP ICIKFCDMPV FENSRAKSNG MRFKLHDTLD YECYDGYEIS YGNTTGSIVC GEDGWSHFPT CYNSSEKCGP PPPISNGDTT SFLLKVYVPQ SRVEYQCQSY YELQGSNYVT CSNGEWSEPP RCIHPCIITE ENMNKNNIQL KGKSDIKYYA KTGDTIEFMC KLGYNANTSV LSFQAVCREG IVEYPRCE
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