About ATP-dependent RNA helicase DDX1
ATP-dependent RNA helicase DDX1 (DDX1) is a protein
from Homo sapiens identified by UniProt accession
Q92499, 740 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase DDX1 |
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| UniProt accession | Q92499 |
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| Gene | DDX1 |
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| Organism | Homo sapiens |
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| Length | 740 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (89)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.39
- neurodegenerative disease · score 0.37
- urate measurement · score 0.37
- creatinine measurement · score 0.36
- Nephroblastoma · score 0.31
- cystatin C measurement · score 0.27
- blood urea nitrogen measurement · score 0.25
- uric acid measurement · score 0.25
- kidney volume · score 0.23
- serum urea measurement · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92499-F1 | alphafold | PREDICTED | 86.63 | — |
Amino-acid sequence (740 residues)
MAAFSEMGVM PEIAQAVEEM DWLLPTDIQA ESIPLILGGG DVLMAAETGS GKTGAFSIPV IQIVYETLKD QQEGKKGKTT IKTGASVLNK WQMNPYDRGS AFAIGSDGLC CQSREVKEWH GCRATKGLMK GKHYYEVSCH DQGLCRVGWS TMQASLDLGT DKFGFGFGGT GKKSHNKQFD NYGEEFTMHD TIGCYLDIDK GHVKFSKNGK DLGLAFEIPP HMKNQALFPA CVLKNAELKF NFGEEEFKFP PKDGFVALSK APDGYIVKSQ HSGNAQVTQT KFLPNAPKAL IVEPSRELAE QTLNNIKQFK KYIDNPKLRE LLIIGGVAAR DQLSVLENGV DIVVGTPGRL DDLVSTGKLN LSQVRFLVLD EADGLLSQGY SDFINRMHNQ IPQVTSDGKR LQVIVCSATL HSFDVKKLSE KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP KTDRLWERLG KSHIRTDDVH AKDNTRPGAN SPEMWSEAIK ILKGEYAVRA IKEHKMDQAI IFCRTKIDCD NLEQYFIQQG GGPDKKGHQF SCVCLHGDRK PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSSRGKGCYN TRLKEDGGCT IWYNEMQLLS EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGS YKGHVDILAP TVQELAALEK EAQTSFLHLG YLPNQLFRTF
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