(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)

About (3R)-3-hydroxyacyl-CoA dehydrogenase

(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8) is a protein from Homo sapiens identified by UniProt accession Q92506, 261 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	(3R)-3-hydroxyacyl-CoA dehydrogenase
UniProt accession	Q92506
Gene	HSD17B8
Organism	Homo sapiens
Length	261 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

MODY · score 0.07
blood protein measurement · score 0.06
hyperproinsulinemia · score 0.05
Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.04
glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
diabetes mellitus, permanent neonatal 4 · score 0.03
asthma · score 0.03
diabetes mellitus, transient neonatal, 3 · score 0.03
transient neonatal diabetes mellitus · score 0.03
Obesity · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92506-F1	alphafold	PREDICTED	93.74	—

Amino-acid sequence (261 residues)

MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards