About Tribbles homolog 2
Tribbles homolog 2 (TRIB2) is a protein
from Homo sapiens identified by UniProt accession
Q92519, 343 residues long.
MolForge cross-references it against 0 known binders and
197 disease associations.
Target properties
| Protein name | Tribbles homolog 2 |
|---|
| UniProt accession | Q92519 |
|---|
| Gene | TRIB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 343 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (197)
Diseases linked to this target (Open Targets).
- platelet count · score 0.48
- monocyte count · score 0.47
- neutrophil count · score 0.45
- hemoglobin measurement · score 0.45
- reticulocyte count · score 0.44
- electrocardiography · score 0.43
- hematocrit · score 0.43
- platelet crit · score 0.42
- leukocyte count · score 0.41
- body mass index · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92519-F1 | alphafold | PREDICTED | 80.45 | — |
Amino-acid sequence (343 residues)
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII LGETKAYVFF ERSYGDMHSF VRTCKKLREE EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ EILDHPWFST DFSVSNSAYG AKEVSDQLVP DVNMEENLDP FFN
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