Proteasome inhibitor PI31 subunit (PSMF1)

About Proteasome inhibitor PI31 subunit

Proteasome inhibitor PI31 subunit (PSMF1) is a protein from Homo sapiens identified by UniProt accession Q92530, 271 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Proteasome inhibitor PI31 subunit
UniProt accession	Q92530
Gene	PSMF1
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
lung adenocarcinoma · score 0.29
urinary bladder cancer · score 0.28
squamous cell lung carcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28
gastric adenocarcinoma · score 0.28
Red cell distribution width · score 0.22
neurodegenerative disease · score 0.19
white matter microstructure measurement · score 0.15
blood protein measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92530-F1	alphafold	PREDICTED	74.84	—

Amino-acid sequence (271 residues)

MAGLEVLFAS AAPAITCRQD ALVCFLHWEV VTHGYFGLGV GDQPGPNDKK SELLPAGWNN NKDLYVLRYE YKDGSRKLLV KAITVESSMI LNVLEYGSQQ VADLTLNLDD YIDAEHLGDF HRTYKNSEEL RSRIVSGIIT PIHEQWEKAN VSSPHREFPP ATAREVDPLR IPPHHPHTSR QPPWCDPLGP FVVGGEDLDP FGPRRGGMIV DPLRSGFPRA LIDPSSGLPN RLPPGAVPPG ARFDPFGPIG TSPPGPNPDH LPPPGYDDMY L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards