Y+L amino acid transporter 2 (SLC7A6)

About Y+L amino acid transporter 2

Y+L amino acid transporter 2 (SLC7A6) is a protein from Homo sapiens identified by UniProt accession Q92536, 515 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Y+L amino acid transporter 2
UniProt accession	Q92536
Gene	SLC7A6
Organism	Homo sapiens
Length	515 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

blood metabolite measurement · score 0.33
serum metabolite measurement · score 0.31
glomerular filtration rate · score 0.31
metabolite measurement · score 0.21
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
body mass index · score 0.14
self reported educational attainment · score 0.14
creatinine measurement · score 0.13
lymphocyte count · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92536-F1	alphafold	PREDICTED	83.22	—

Amino-acid sequence (515 residues)

MEAREPGRPT PTYHLVPNTS QSQVEEDVSS PPQRSSETMQ LKKEISLLNG VSLVVGNMIG SGIFVSPKGV LVHTASYGMS LIVWAIGGLF SVVGALCYAE LGTTITKSGA SYAYILEAFG GFIAFIRLWV SLLVVEPTGQ AIIAITFANY IIQPSFPSCD PPYLACRLLA AACICLLTFV NCAYVKWGTR VQDTFTYAKV VALIAIIVMG LVKLCQGHSE HFQDAFEGSS WDMGNLSLAL YSALFSYSGW DTLNFVTEEI KNPERNLPLA IGISMPIVTL IYILTNVAYY TVLNISDVLS SDAVAVTFAD QTFGMFSWTI PIAVALSCFG GLNASIFASS RLFFVGSREG HLPDLLSMIH IERFTPIPAL LFNCTMALIY LIVEDVFQLI NYFSFSYWFF VGLSVVGQLY LRWKEPKRPR PLKLSVFFPI VFCICSVFLV IVPLFTDTIN SLIGIGIALS GVPFYFMGVY LPESRRPLFI RNVLAAITRG TQQLCFCVLT ELDVAEEKKD ERKTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards