About Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) is a protein
from Homo sapiens identified by UniProt accession
Q92538, 1860 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 |
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| UniProt accession | Q92538 |
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| Gene | GBF1 |
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| Organism | Homo sapiens |
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| Length | 1860 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth Disease, axonal, type 2GG · score 0.69
- Autosomal dominant intermediate Charcot-Marie-Tooth disease type A · score 0.65
- neurodegenerative disease · score 0.52
- Parkinson disease · score 0.49
- Alzheimer disease · score 0.45
- multiple sclerosis · score 0.45
- lysosomal storage disease · score 0.45
- mean corpuscular volume · score 0.36
- cognitive function measurement · score 0.29
- self reported educational attainment · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92538-F1 | alphafold | PREDICTED | 70.34 | — |
Amino-acid sequence (1860 residues)
MVDKNIYIIQ GEINIVVGAI KRNARWSTHT PLDEERDPLL HSFGHLKEVL NSITELSEIE PNVFLRPFLE VIRSEDTTGP ITGLALTSVN KFLSYALIDP THEGTAEGME NMADAVTHAR FVGTDPASDE VVLMKILQVL RTLLLTPVGA HLTNESVCEI MQSCFRICFE MRLSELLRKS AEHTLVDMVQ LLFTRLPQFK EEPKNYVGTN MKKLKMRAGG MSDSSKWKKQ KRSPRPPRHM TKVTPGSELP TPNGTTLSSN LTGGMPFIDV PTPISSASSE AASAVVSPST DSGLEFSSQT TSKEDLTDLE QPGSPGYSTA TEPGSSELGV PEQPDLQQEG THVEKSQSAS VESIPEVLEE CTSPADHSDS ASVHDMDYVN PRGVRFTQSS QKEGTALVPY GLPCIRELFR FLISLTNPHD RHNSEVMIHM GLHLLTVALE SAPVAQCQTL LGLIKDEMCR HLFQLLSIER LNLYAASLRV CFLLFESMRE HLKFQMEMYI KKLMEIITVE NPKMPYEMKE MALEAIVQLW RIPSFVTELY INYDCDYYCS NLFEELTKLL SKNAFPVSGQ LYTTHLLSLD ALLTVIDSTE AHCQAKVLNS LTQQEKKETA RPSCEIVDGT REASNTERTA SDGKAVGMAS DIPGLHLPGG GRLPPEHGKS GCSDLEEAVD SGADKKFARK PPRFSCLLPD PRELIEIKNK KKLLITGTEQ FNQKPKKGIQ FLQEKGLLTI PMDNTEVAQW LRENPRLDKK MIGEFVSDRK NIDLLESFVS TFSFQGLRLD EALRLYLEAF RLPGEAPVIQ RLLEAFTERW MNCNGSPFAN SDACFSLAYA VIMLNTDQHN HNVRKQNAPM TLEEFRKNLK GVNGGKDFEQ DILEDMYHAI KNEEIVMPEE QTGLVRENYV WNVLLHRGAT PEGIFLRVPT ASYDLDLFTM TWGPTIAALS YVFDKSLEET IIQKAISGFR KCAMISAHYG LSDVFDNLII SLCKFTALSS ESIENLPSVF GSNPKAHIAA KTVFHLAHRH GDILREGWKN IMEAMLQLFR AQLLPKAMIE VEDFVDPNGK ISLQREETPS NRGESTVLSF VSWLTLSGPE QSSVRGPSTE NQEAKRVALE CIKQCDPEKM ITESKFLQLE SLQELMKALV SVTPDEETYD EEDAAFCLEM LLRIVLENRD RVGCVWQTVR DHLYHLCVQA QDFCFLVERA VVGLLRLAIR LLRREEISAQ VLLSLRILLL MKPSVLSRVS HQVAYGLHEL LKTNAANIHS GDDWATLFTL LECIGSGVKP PAALQATARA DAPDAGAQSD SELPSYHQND VSLDRGYTSD SEVYTDHGRP GKIHRSATDA DVVNSGWLVV GKDDVDNSKP GPSRPGPSPL INQYSLTVGL DLGPHDTKSL LKCVESLSFI VRDAAHITPD NFELCVKTLR IFVEASLNGG CKSQEKRGKS HKYDSKGNRF KKKSKEGSML RRPRTSSQHA SRGGQSDDDE DEGVPASYHT VSLQVSQDLL DLMHTLHTRA ASIYSSWAEE QRHLETGGQK IEADSRTLWA HCWCPLLQGI ACLCCDARRQ VRMQALTYLQ RALLVHDLQK LDALEWESCF NKVLFPLLTK LLENISPADV GGMEETRMRA STLLSKVFLQ HLSPLLSLST FAALWLTILD FMDKYMHAGS SDLLSEAIPE SLKNMLLVMD TAEIFHSADA RGGGPSALWE ITWERIDCFL PHLRDELFKQ TVIQDPMPME PQGQKPLASA HLTSAAGDTR TPGHPPPPEI PSELGACDFE KPESPRAASS SSPGSPVASS PSRLSPTPDG PPPLAQPPLI LQPLASPLQV GVPPMTLPII LNPALIEATS PVPLLATPRP TDPIPTSEVN
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