About Nicastrin
Nicastrin (NCSTN) is a protein
from Homo sapiens identified by UniProt accession
Q92542, 709 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Target properties
| Protein name | Nicastrin |
|---|
| UniProt accession | Q92542 |
|---|
| Gene | NCSTN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 709 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (113)
Diseases linked to this target (Open Targets).
- acne inversa, familial, 1 · score 0.69
- neurodegenerative disease · score 0.53
- Alzheimer disease · score 0.39
- hidradenitis suppurativa · score 0.38
- Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome · score 0.37
- Abnormality of the skin · score 0.34
- Dementia · score 0.32
- Desmoid-type fibromatosis · score 0.29
- head and neck squamous cell carcinoma · score 0.28
- breast adenocarcinoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92542-F1 | alphafold | PREDICTED | 89.37 | — |
Amino-acid sequence (709 residues)
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQCYQDHN LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF SINPEIVCDP LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENVD SFVELGQVAL RTSLELWMHT DPVSQKNESV RNQVEDLLAT LEKSGAGVPA VILRRPNQSQ PLPPSSLQRF LRARNISGVV LADHSGAFHN KYYQSIYDTA ENINVSYPEW LSPEEDLNFV TDTAKALADV ATVLGRALYE LAGGTNFSDT VQADPQTVTR LLYGFLIKAN NSWFQSILRQ DLRSYLGDGP LQHYIAVSSP TNTTYVVQYA LANLTGTVVN LTREQCQDPS KVPSENKDLY EYSWVQGPLH SNETDRLPRC VRSTARLARA LSPAFELSQW SSTEYSTWTE SRWKDIRARI FLIASKELEL ITLTVGFGIL IFSLIVTYCI NAKADVLFIA PREPGAVSY
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