About Sorting nexin-19
Sorting nexin-19 (SNX19) is a protein
from Homo sapiens identified by UniProt accession
Q92543, 992 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Sorting nexin-19 |
|---|
| UniProt accession | Q92543 |
|---|
| Gene | SNX19 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 992 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.49
- body mass index · score 0.46
- pulse pressure measurement · score 0.45
- body fat percentage · score 0.44
- lean body mass · score 0.43
- fat body mass · score 0.41
- body weight · score 0.37
- autism spectrum disorder · score 0.35
- neurofibrillary tangles measurement · score 0.33
- bipolar disorder · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92543-F1 | alphafold | PREDICTED | 60.35 | — |
Amino-acid sequence (992 residues)
MKTETVPPFQ ETPAGSSCHL NNLLSSRKLM AVGVLLGWLL VIHLLVNVWL LCLLSALLVV LGGWLGSSLA GVASGRLHLE RFIPLATCPP CPEAERQLER EINRTIQMII RDFVLSWYRS VSQEPAFEEE MEAAMKGLVQ ELRRRMSVMD SHAVAQSVLT LCGCHLQSYI QAKEATAGKN GPVEPSHLWE AYCRATAPHP AVHSPSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE LITCNVILPL ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL PEGRASPVAA PVFLSYSEPE GSAGPSPEVE EGHEAVEGDL GGMCEERKVG NNSSHFLQPN VRGPLFLCED SELESPLSEL GKETIMLMTP GSFLSDRIQD ALCALESSQA LEPKDGEASE GAEAEEGPGT ETETGLPVST LNSCPEIHID TADKEIEQGD VTASVTALLE GPEKTCPSRP SCLEKDLTND VSSLDPTLPP VLLSSSPPGP LSSATFSFEP LSSPDGPVII QNLRITGTIT AREHSGTGFH PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR KFIKNVKGPK KLFPDLPLGN MDSDRVEARK SLLESFLKQL CAIPEIANSE EVQEFLALNT DARIAFVKKP FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP TEELSEAETE SKPQTEGKKA SKSRLRFSSS KISPALSVTE AQDKILYCLQ EGNVESETLS MSAMESFIEK QTKLLEMQPT KAPEKDPEQP PKGRVDSCVS DAAVPAQDPS NSDPGTETEL ADTALDLLLL LLTEQWKWLC TENMQKFLRL IFGTLVQRWL EVQVANLTSP QRWVQYLLLL QESIWPGGVL PKFPRPVRTQ EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CRLSWGLVLE SLQQPLINRH LIYCLGDIIL EFLDLSASVE ESAATTSASD TPGNSKRMGV SS
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