About Transmembrane protein 131
Transmembrane protein 131 (TMEM131) is a protein
from Homo sapiens identified by UniProt accession
Q92545, 1883 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Transmembrane protein 131 |
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| UniProt accession | Q92545 |
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| Gene | TMEM131 |
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| Organism | Homo sapiens |
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| Length | 1883 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92545-F1 | alphafold | PREDICTED | 59.44 | — |
Amino-acid sequence (1883 residues)
MGKRAGGGAT GATTAAVSTS AGAGLEPAAA RSGGPRSAAA GLLGALHLVM TLVVAAARAE KEAFVQSESI IEVLRFDDGG LLQTETTLGL SSYQQKSISL YRGNCRPIRF EPPMLDFHEQ PVGMPKMEKV YLHNPSSEET ITLVSISATT SHFHASFFQN RKILPGGNTS FDVVFLARVV GNVENTLFIN TSNHGVFTYQ VFGVGVPNPY RLRPFLGARV PVNSSFSPII NIHNPHSEPL QVVEMYSSGG DLHLELPTGQ QGGTRKLWEI PPYETKGVMR ASFSSREADN HTAFIRIKTN ASDSTEFIIL PVEVEVTTAP GIYSSTEMLD FGTLRTQDLP KVLNLHLLNS GTKDVPITSV RPTPQNDAIT VHFKPITLKA SESKYTKVAS ISFDASKAKK PSQFSGKITV KAKEKSYSKL EIPYQAEVLD GYLGFDHAAT LFHIRDSPAD PVERPIYLTN TFSFAILIHD VLLPEEAKTM FKVHNFSKPV LILPNESGYI FTLLFMPSTS SMHIDNNILL ITNASKFHLP VRVYTGFLDY FVLPPKIEER FIDFGVLSAT EASNILFAII NSNPIELAIK SWHIIGDGLS IELVAVERGN RTTIISSLPE FEKSSLSDQS SVTLASGYFA VFRVKLTAKK LEGIHDGAIQ ITTDYEILTI PVKAVIAVGS LTCFPKHVVL PPSFPGKIVH QSLNIMNSFS QKVKIQQIRS LSEDVRFYYK RLRGNKEDLE PGKKSKIANI YFDPGLQCGD HCYVGLPFLS KSEPKVQPGV AMQEDMWDAD WDLHQSLFKG WTGIKENSGH RLSAIFEVNT DLQKNIISKI TAELSWPSIL SSPRHLKFPL TNTNCSSEEE ITLENPADVP VYVQFIPLAL YSNPSVFVDK LVSRFNLSKV AKIDLRTLEF QVFRNSAHPL QSSTGFMEGL SRHLILNLIL KPGEKKSVKV KFTPVHNRTV SSLIIVRNNL TVMDAVMVQG QGTTENLRVA GKLPGPGSSL RFKITEALLK DCTDSLKLRE PNFTLKRTFK VENTGQLQIH IETIEISGYS CEGYGFKVVN CQEFTLSANA SRDIIILFTP DFTASRVIRE LKFITTSGSE FVFILNASLP YHMLATCAEA LPRPNWELAL YIIISGIMSA LFLLVIGTAY LEAQGIWEPF RRRLSFEASN PPFDVGRPFD LRRIVGISSE GNLNTLSCDP GHSRGFCGAG GSSSRPSAGS HKQCGPSVHP HSSHSNRNSA DVENVRAKNS SSTSSRTSAQ AASSQSANKT SPLVLDSNTV TQGHTAGRKS KGAKQSQHGS QHHAHSPLEQ HPQPPLPPPV PQPQEPQPER LSPAPLAHPS HPERASSARH SSEDSDITSL IEAMDKDFDH HDSPALEVFT EQPPSPLPKS KGKGKPLQRK VKPPKKQEEK EKKGKGKPQE DELKDSLADD DSSSTTTETS NPDTEPLLKE DTEKQKGKQA MPEKHESEMS QVKQKSKKLL NIKKEIPTDV KPSSLELPYT PPLESKQRRN LPSKIPLPTA MTSGSKSRNA QKTKGTSKLV DNRPPALAKF LPNSQELGNT SSSEGEKDSP PPEWDSVPVH KPGSSTDSLY KLSLQTLNAD IFLKQRQTSP TPASPSPPAA PCPFVARGSY SSIVNSSSSS DPKIKQPNGS KHKLTKAASL PGKNGNPTFA AVTAGYDKSP GGNGFAKVSS NKTGFSSSLG ISHAPVDSDG SDSSGLWSPV SNPSSPDFTP LNSFSAFGNS FNLTGEVFSK LGLSRSCNQA SQRSWNEFNS GPSYLWESPA TDPSPSWPAS SGSPTHTATS VLGNTSGLWS TTPFSSSIWS SNLSSALPFT TPANTLASIG LMGTENSPAP HAPSTSSPAD DLGQTYNPWR IWSPTIGRRS SDPWSNSHFP HEN
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