About Ubiquitin carboxyl-terminal hydrolase BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) is a protein
from Homo sapiens identified by UniProt accession
Q92560, 729 residues long.
MolForge cross-references it against 0 known binders and
339 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase BAP1 |
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| UniProt accession | Q92560 |
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| Gene | BAP1 |
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| Organism | Homo sapiens |
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| Length | 729 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (339)
Diseases linked to this target (Open Targets).
- BAP1-related tumor predisposition syndrome · score 0.82
- Uveal Melanoma · score 0.76
- Pleural Mesothelioma · score 0.66
- clear cell renal carcinoma · score 0.63
- hereditary neoplastic syndrome · score 0.58
- Inherited cancer-predisposing syndrome · score 0.57
- hepatocellular carcinoma · score 0.53
- Neurodevelopmental disorder · score 0.52
- Uveal melanoma · score 0.49
- cholangiocarcinoma · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92560-F1 | alphafold | PREDICTED | 62.87 | — |
Amino-acid sequence (729 residues)
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGLS AVRTMEAFHF VSYVPITGRL FELDGLKVYP IDHGPWGEDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRIK YEARLHVLKV NRQTVLEALQ QLIRVTQPEL IQTHKSQESQ LPEESKSASN KSPLVLEANR APAASEGNHT DGAEEAAGSC AQAPSHSPPN KPKLVVKPPG SSLNGVHPNP TPIVQRLPAF LDNHNYAKSP MQEEEDLAAG VGRSRVPVRP PQQYSDDEDD YEDDEEDDVQ NTNSALRYKG KGTGKPGALS GSADGQLSVL QPNTINVLAE KLKESQKDLS IPLSIKTSSG AGSPAVAVPT HSQPSPTPSN ESTDTASEIG SAFNSPLRSP IRSANPTRPS SPVTSHISKV LFGEDDSLLR VDCIRYNRAV RDLGPVISTG LLHLAEDGVL SPLALTEGGK GSSPSIRPIQ GSQGSSSPVE KEVVEATDSR EKTGMVRPGE PLSGEKYSPK ELLALLKCVE AEIANYEACL KEEVEKRKKF KIDDQRRTHN YDEFICTFIS MLAQEGMLAN LVEQNISVRR RQGVSIGRLH KQRKPDRRKR SRPYKAKRQ
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