Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP)

About Phytanoyl-CoA hydroxylase-interacting protein

Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP) is a protein from Homo sapiens identified by UniProt accession Q92561, 330 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Phytanoyl-CoA hydroxylase-interacting protein
UniProt accession	Q92561
Gene	PHYHIP
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.20
glioblastoma multiforme · score 0.05
atypical teratoid rhabdoid tumor · score 0.04
medulloblastoma · score 0.04
central nervous system cancer · score 0.03
psoriasis · score 0.03
astrocytoma · score 0.02
ependymoma · score 0.02
adrenal cortex carcinoma · score 0.02
oligodendroglioma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92561-F1	alphafold	PREDICTED	90.10	—

Amino-acid sequence (330 residues)

MELLSTPHSI EINNITCDSF RISWAMEDSD LERVTHYFID LNKKENKNSN KFKHRDVPTK LVAKAVPLPM TVRGHWFLSP RTEYSVAVQT AVKQSDGEYL VSGWSETVEF CTGDYAKEHL AQLQEKAEQI AGRMLRFSVF YRNHHKEYFQ HARTHCGNML QPYLKDNSGS HGSPTSGMLH GVFFSCNTEF NTGQPPQDSP YGRWRFQIPA QRLFNPSTNL YFADFYCMYT AYHYAILVLA PKGSLGDRFC RDRLPLLDIA CNKFLTCSVE DGELVFRHAQ DLILEIIYTE PVDLSLGTLG EISGHQLMSL STADAKKDPS CKTCNISVGR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards