About Sodium/hydrogen exchanger 6
Sodium/hydrogen exchanger 6 (SLC9A6) is a protein
from Homo sapiens identified by UniProt accession
Q92581, 701 residues long.
MolForge cross-references it against 0 known binders and
122 disease associations.
Target properties
| Protein name | Sodium/hydrogen exchanger 6 |
|---|
| UniProt accession | Q92581 |
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| Gene | SLC9A6 |
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| Organism | Homo sapiens |
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| Length | 701 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (122)
Diseases linked to this target (Open Targets).
- Christianson syndrome · score 0.81
- Intellectual disability · score 0.54
- genetic disorder · score 0.45
- Microcephaly · score 0.40
- neurodegenerative disease · score 0.37
- microcephaly · score 0.37
- Seizure · score 0.34
- Global developmental delay · score 0.33
- Short stature · score 0.30
- chorea · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92581-F1 | alphafold | PREDICTED | 70.60 | — |
Amino-acid sequence (701 residues)
MARRGWRRAP LRRGVGSSPR ARRLMRPLWL LLAVGVFDWA GASDGGGGEA RAMDEEIVSE KQAEESHRQD SANLLIFILL LTLTILTIWL FKHRRARFLH ETGLAMIYGL LVGLVLRYGI HVPSDVNNVT LSCEVQSSPT TLLVNVSGKF YEYMLKGEIS SHELNNVQDN EMLRKVTFDP EVFFNILLPP IIFYAGYSLK RRHFFRNLGS ILAYAFLGTA ISCFVIGSIM YGCVTLMKVT GQLAGDFYFT DCLLFGAIVS ATDPVTVLAI FHELQVDVEL YALLFGESVL NDAVAIVLSS SIVAYQPAGD NSHTFDVTAM FKSIGIFLGI FSGSFAMGAA TGVVTALVTK FTKLREFQLL ETGLFFLMSW STFLLAEAWG FTGVVAVLFC GITQAHYTYN NLSTESQHRT KQLFELLNFL AENFIFSYMG LTLFTFQNHV FNPTFVVGAF VAIFLGRAAN IYPLSLLLNL GRRSKIGSNF QHMMMFAGLR GAMAFALAIR DTATYARQMM FSTTLLIVFF TVWVFGGGTT AMLSCLHIRV GVDSDQEHLG VPENERRTTK AESAWLFRMW YNFDHNYLKP LLTHSGPPLT TTLPACCGPI ARCLTSPQAY ENQEQLKDDD SDLILNDGDI SLTYGDSTVN TEPATSSAPR RFMGNSSEDA LDRELAFGDH ELVIRGTRLV LPMDDSEPPL NLLDNTRHGP A
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