Protein NDRG1 (NDRG1)

About Protein NDRG1

Protein NDRG1 (NDRG1) is a protein from Homo sapiens identified by UniProt accession Q92597, 394 residues long. MolForge cross-references it against 0 known binders and 481 disease associations.

Target properties

Protein name	Protein NDRG1
UniProt accession	Q92597
Gene	NDRG1
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (481)

Diseases linked to this target (Open Targets).

Charcot-Marie-Tooth disease type 4D · score 0.74
Charcot-Marie-Tooth disease type 4 · score 0.55
genetic disorder · score 0.45
Charcot-Marie-Tooth disease · score 0.41
kidney neoplasm · score 0.37
gastric carcinoma · score 0.37
prostate adenocarcinoma · score 0.37
colorectal adenocarcinoma · score 0.37
bile duct carcinoma · score 0.37
lung carcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92597-F1	alphafold	PREDICTED	77.98	—

Amino-acid sequence (394 residues)

MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards