About ER degradation-enhancing alpha-mannosidase-like protein 1
ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1) is a protein
from Homo sapiens identified by UniProt accession
Q92611, 657 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | ER degradation-enhancing alpha-mannosidase-like protein 1 |
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| UniProt accession | Q92611 |
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| Gene | EDEM1 |
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| Organism | Homo sapiens |
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| Length | 657 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.62
- PHF-tau measurement · score 0.20
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07
- thrombocytopenia 4 · score 0.07
- platelet-type bleeding disorder 15 · score 0.06
- autosomal dominant macrothrombocytopenia · score 0.06
- smoking status measurement · score 0.05
- smoking initiation · score 0.05
- bleeding disorder, platelet-type, 24 · score 0.05
- platelet-type bleeding disorder 10 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92611-F1 | alphafold | PREDICTED | 83.87 | — |
Amino-acid sequence (657 residues)
MQWRALVLGL VLLRLGLHGV LWLVFGLGPS MGFYQRFPLS FGFQRLRSPD GPASPTSGPV GRPGGVSGPS WLQPPGTGAA QSPRKAPRRP GPGMCGPANW GYVLGGRGRG PDEYEKRYSG AFPPQLRAQM RDLARGMFVF GYDNYMAHAF PQDELNPIHC RGRGPDRGDP SNLNINDVLG NYSLTLVDAL DTLAIMGNSS EFQKAVKLVI NTVSFDKDST VQVFEATIRV LGSLLSAHRI ITDSKQPFGD MTIKDYDNEL LYMAHDLAVR LLPAFENTKT GIPYPRVNLK TGVPPDTNNE TCTAGAGSLL VEFGILSRLL GDSTFEWVAR RAVKALWNLR SNDTGLLGNV VNIQTGHWVG KQSGLGAGLD SFYEYLLKSY ILFGEKEDLE MFNAAYQSIQ NYLRRGREAC NEGEGDPPLY VNVNMFSGQL MNTWIDSLQA FFPGLQVLIG DVEDAICLHA FYYAIWKRYG ALPERYNWQL QAPDVLFYPL RPELVESTYL LYQATKNPFY LHVGMDILQS LEKYTKVKCG YATLHHVIDK STEDRMESFF LSETCKYLYL LFDEDNPVHK SGTRYMFTTE GHIVSVDEHL RELPWKEFFS EEGGQDQGGK SVHRPKPHEL KVINSSSNCN RVPDERRYSL PLKSIYMRQI DQMVGLI
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