About La-related protein 4B
La-related protein 4B (LARP4B) is a protein
from Homo sapiens identified by UniProt accession
Q92615, 738 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | La-related protein 4B |
|---|
| UniProt accession | Q92615 |
|---|
| Gene | LARP4B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 738 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (173)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.40
- creatinine measurement · score 0.36
- reticulocyte count · score 0.34
- autism spectrum disorder · score 0.33
- basophil count · score 0.33
- eosinophil count · score 0.33
- prostate carcinoma · score 0.29
- basophil percentage of leukocytes · score 0.29
- eosinophil percentage of leukocytes · score 0.28
- reticulocyte measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92615-F1 | alphafold | PREDICTED | 52.77 | — |
Amino-acid sequence (738 residues)
MTSDQDAKVV AEPQTQRVQE GKDSAHLMNG PISQTTSQTS SIPPLSQVPA TKVSELNPNA EVWGAPVLHL EASSAADGVS AAWEEVAGHH ADRGPQGSDA NGDGDQGHEN AALPDPQESD PADMNALALG PSEYDSLPEN SETGGNESQP DSQEDPREVL KKTLEFCLSR ENLASDMYLI SQMDSDQYVP ITTVANLDHI KKLSTDVDLI VEVLRSLPLV QVDEKGEKVR PNQNRCIVIL REISESTPVE EVEALFKGDN LPKFINCEFA YNDNWFITFE TEADAQQAYK YLREEVKTFQ GKPIKARIKA KAIAINTFLP KNGFRPLDVS LYAQQRYATS FYFPPMYSPQ QQFPLYSLIT PQTWSATHSY LDPPLVTPFP NTGFINGFTS PAFKPAASPL TSLRQYPPRS RNPSKSHLRH AIPSAERGPG LLESPSIFNF TADRLINGVR SPQTRQAGQT RTRIQNPSAY AKREAGPGRV EPGSLESSPG LGRGRKNSFG YRKKREEKFT SSQTQSPTPP KPPSPSFELG LSSFPPLPGA AGNLKTEDLF ENRLSSLIIG PSKERTLSAD ASVNTLPVVV SREPSVPASC AVSATYERSP SPAHLPDDPK VAEKQRETHS VDRLPSALTA TACKSVQVNG AATELRKPSY AEICQRTSKE PPSSPLQPQK EQKPNTVGCG KEEKKLAEPA ERYREPPALK STPGAPRDQR RPAGGRPSPS AMGKRLSREQ STPPKSPQ
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