About Stalled ribosome sensor GCN1
Stalled ribosome sensor GCN1 (GCN1) is a protein
from Homo sapiens identified by UniProt accession
Q92616, 2671 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Stalled ribosome sensor GCN1 |
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| UniProt accession | Q92616 |
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| Gene | GCN1 |
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| Organism | Homo sapiens |
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| Length | 2671 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- bipolar disorder · score 0.22
- platelet count · score 0.18
- body height · score 0.18
- fetal akinesia deformation sequence · score 0.12
- fetal akinesia deformation sequence 1 · score 0.12
- arthrogryposis multiplex congenita · score 0.12
- MODY · score 0.06
- cancer · score 0.06
- drug use measurement · score 0.04
- hyperproinsulinemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92616-F1 | alphafold | PREDICTED | 82.28 | — |
Amino-acid sequence (2671 residues)
MAADTQVSET LKRFAGKVTT ASVKERREIL SELGKCVAGK DLPEGAVKGL CKLFCLTLHR YRDAASRRAL QAAIQQLAEA QPEATAKNLL HSLQSSGIGS KAGVPSKSSG SAALLALTWT CLLVRIVFPS RAKRQGDIWN KLVEVQCLLL LEVLGGSHKH AVDGAVKKLT KLWKENPGLV EQYLSAILSL EPNQNYAGML GLLVQFCTSH KEMDVVSQHK SALLDFYMKN ILMSKVKPPK YLLDSCAPLL RYLSHSEFKD LILPTIQKSL LRSPENVIET ISSLLASVTL DLSQYAMDIV KGLAGHLKSN SPRLMDEAVL ALRNLARQCS DSSAMESLTK HLFAILGGSE GKLTVVAQKM SVLSGIGSVS HHVVSGPSSQ VLNGIVAELF IPFLQQEVHE GTLVHAVSVL ALWCNRFTME VPKKLTEWFK KAFSLKTSTS AVRHAYLQCM LASYRGDTLL QALDLLPLLI QTVEKAASQS TQVPTITEGV AAALLLLKLS VADSQAEAKL SSFWQLIVDE KKQVFTSEKF LVMASEDALC TVLHLTERLF LDHPHRLTGN KVQQYHRALV AVLLSRTWHV RRQAQQTVRK LLSSLGGFKL AHGLLEELKT VLSSHKVLPL EALVTDAGEV TEAGKAYVPP RVLQEALCVI SGVPGLKGDV TDTEQLAQEM LIISHHPSLV AVQSGLWPAL LARMKIDPEA FITRHLDQII PRMTTQSPLN QSSMNAMGSL SVLSPDRVLP QLISTITASV QNPALRLVTR EEFAIMQTPA GELYDKSIIQ SAQQDSIKKA NMKRENKAYS FKEQIIELEL KEEIKKKKGI KEEVQLTSKQ KEMLQAQLDR EAQVRRRLQE LDGELEAALG LLDIILAKNP SGLTQYIPVL VDSFLPLLKS PLAAPRIKNP FLSLAACVMP SRLKALGTLV SHVTLRLLKP ECVLDKSWCQ EELSVAVKRA VMLLHTHTIT SRVGKGEPGA APLSAPAFSL VFPFLKMVLT EMPHHSEEEE EWMAQILQIL TVQAQLRASP NTPPGRVDEN GPELLPRVAM LRLLTWVIGT GSPRLQVLAS DTLTTLCASS SGDDGCAFAE QEEVDVLLCA LQSPCASVRE TVLRGLMELH MVLPAPDTDE KNGLNLLRRL WVVKFDKEEE IRKLAERLWS MMGLDLQPDL CSLLIDDVIY HEAAVRQAGA EALSQAVARY QRQAAEVMGR LMEIYQEKLY RPPPVLDALG RVISESPPDQ WEARCGLALA LNKLSQYLDS SQVKPLFQFF VPDALNDRHP DVRKCMLDAA LATLNTHGKE NVNSLLPVFE EFLKNAPNDA SYDAVRQSVV VLMGSLAKHL DKSDPKVKPI VAKLIAALST PSQQVQESVA SCLPPLVPAI KEDAGGMIQR LMQQLLESDK YAERKGAAYG LAGLVKGLGI LSLKQQEMMA ALTDAIQDKK NFRRREGALF AFEMLCTMLG KLFEPYVVHV LPHLLLCFGD GNQYVREAAD DCAKAVMSNL SAHGVKLVLP SLLAALEEES WRTKAGSVEL LGAMAYCAPK QLSSCLPNIV PKLTEVLTDS HVKVQKAGQQ ALRQIGSVIR NPEILAIAPV LLDALTDPSR KTQKCLQTLL DTKFVHFIDA PSLALIMPIV QRAFQDRSTD TRKMAAQIIG NMYSLTDQKD LAPYLPSVTP GLKASLLDPV PEVRTVSAKA LGAMVKGMGE SCFEDLLPWL METLTYEQSS VDRSGAAQGL AEVMAGLGVE KLEKLMPEIV ATASKVDIAP HVRDGYIMMF NYLPITFGDK FTPYVGPIIP CILKALADEN EFVRDTALRA GQRVISMYAE TAIALLLPQL EQGLFDDLWR IRFSSVQLLG DLLFHISGVT GKMTTETASE DDNFGTAQSN KAIITALGVE RRNRVLAGLY MGRSDTQLVV RQASLHVWKI VVSNTPRTLR EILPTLFGLL LGFLASTCAD KRTIAARTLG DLVRKLGEKI LPEIIPILEE GLRSQKSDER QGVCIGLSEI MKSTSRDAVL YFSESLVPTA RKALCDPLEE VREAAAKTFE QLHSTIGHQA LEDILPFLLK QLDDEEVSEF ALDGLKQVMA IKSRVVLPYL VPKLTTPPVN TRVLAFLSSV AGDALTRHLG VILPAVMLAL KEKLGTPDEQ LEMANCQAVI LSVEDDTGHR IIIEDLLEAT RSPEVGMRQA AAIILNIYCS RSKADYTSHL RSLVSGLIRL FNDSSPVVLE ESWDALNAIT KKLDAGNQLA LIEELHKEIR LIGNESKGEH VPGFCLPKKG VTSILPVLRE GVLTGSPEQK EEAAKALGLV IRLTSADALR PSVVSITGPL IRILGDRFSW NVKAALLETL SLLLAKVGIA LKPFLPQLQT TFTKALQDSN RGVRLKAADA LGKLISIHIK VDPLFTELLN GIRAMEDPGV RDTMLQALRF VIQGAGAKVD AVIRKNIVSL LLSMLGHDED NTRISSAGCL GELCAFLTEE ELSAVLQQCL LADVSGIDWM VRHGRSLALS VAVNVAPGRL CAGRYSSDVQ EMILSSATAD RIPIAVSGVR GMGFLMRHHI ETGGGQLPAK LSSLFVKCLQ NPSSDIRLVA EKMIWWANKD PLPPLDPQAI KPILKALLDN TKDKNTVVRA YSDQAIVNLL KMRQGEEVFQ SLSKILDVAS LEVLNEVNRR SLKKLASQAD STEQVDDTIL T
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