About Zinc finger protein 516
Zinc finger protein 516 (ZNF516) is a protein
from Homo sapiens identified by UniProt accession
Q92618, 1163 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Zinc finger protein 516 |
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| UniProt accession | Q92618 |
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| Gene | ZNF516 |
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| Organism | Homo sapiens |
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| Length | 1163 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.51
- leukocyte count · score 0.49
- Red cell distribution width · score 0.49
- monocyte count · score 0.48
- monocyte percentage of leukocytes · score 0.45
- FEV/FVC ratio · score 0.45
- intraocular pressure measurement · score 0.44
- neutrophil percentage of leukocytes · score 0.42
- self reported educational attainment · score 0.42
- bone density · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92618-F1 | alphafold | PREDICTED | 50.61 | — |
Amino-acid sequence (1163 residues)
MDRNREAEME LRRGPSPTRA GRGHEVDGDK ATCHTCCICG KSFPFQSSLS QHMRKHTGEK PYKCPYCDHR ASQKGNLKIH IRSHRTGTLI QGHEPEAGEA PLGEMRASEG LDACASPTKS ASACNRLLNG ASQADGARVL NGASQADSGR VLLRSSKKGA EGSACAPGEA KAAVQCSFCK SQFERKKDLE LHVHQAHKPF KCRLCSYATL REESLLSHIE RDHITAQGPG SGEACVENGK PELSPGEFPC EVCGQAFSQT WFLKAHMKKH RGSFDHGCHI CGRRFKEPWF LKNHMKAHGP KTGSKNRPKS ELDPIATINN VVQEEVIVAG LSLYEVCAKC GNLFTNLDSL NAHNAIHRRV EASRTRAPAE EGAEGPSDTK QFFLQCLNLR PSAAGDSCPG TQAGRRVAEL DPVNSYQAWQ LATRGKVAEP AEYLKYGAWD EALAGDVAFD KDRREYVLVS QEKRKREQDA PAAQGPPRKR ASGPGDPAPA GHLDPRSAAR PNRRAAATTG QGKSSECFEC GKIFRTYHQM VLHSRVHRRA RRERDSDGDR AARARCGSLS EGDSASQPSS PGSACAAADS PGSGLADEAA EDSGEEGAPE PAPGGQPRRC CFSEEVTSTE LSSGDQSHKM GDNASERDTG ESKAGIAASV SILENSSRET SRRQEQHRFS MDLKMPAFHP KQEVPVPGDG VEFPSSTGAE GQTGHPAEKL SDLHNKEHSG GGKRALAPDL MPLDLSARST RDDPSNKETA SSLQAALVVH PCPYCSHKTY YPEVLWMHKR IWHRVSCNSV APPWIQPNGY KSIRSNLVFL SRSGRTGPPP ALGGKECQPL LLARFTRTQV PGGMPGSKSG SSPLGVVTKA ASMPKNKESH SGGPCALWAP GPDGYRQTKP CHGQEPHGAA TQGPLAKPRQ EASSKPVPAP GGGGFSRSAT PTPTVIARAG AQPSANSKPV EKFGVPPAGA GFAPTNKHSA PDSLKAKFSA QPQGPPPAKG EGGAPPLPPR EPPSKAAQEL RTLATCAAGS RGDAALQAQP GVAGAPPVLH SIKQEPVAEG HEKRLDILNI FKTYIPKDFA TLYQGWGVSG PGLEHRGTLR TQARPGEFVC IECGKSFHQP GHLRAHMRAH SVVFESDGPR GSEVHTTSAD APKQGRDHSN TGTVQTVPLR KGT
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