About Amyloid protein-binding protein 2
Amyloid protein-binding protein 2 (APPBP2) is a protein
from Homo sapiens identified by UniProt accession
Q92624, 585 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Amyloid protein-binding protein 2 |
|---|
| UniProt accession | Q92624 |
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| Gene | APPBP2 |
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| Organism | Homo sapiens |
|---|
| Length | 585 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.21
- non-small cell lung carcinoma · score 0.09
- total blood protein measurement · score 0.08
- uncombable hair syndrome · score 0.04
- Griscelli syndrome type 3 · score 0.04
- Griscelli disease · score 0.04
- Griscelli disease type 3 · score 0.04
- neoplasm · score 0.04
- Griscelli disease type 1 · score 0.04
- Waardenburg syndrome type 2A · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92624-F1 | alphafold | PREDICTED | 93.40 | — |
Amino-acid sequence (585 residues)
MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ GRLCQLGSEF CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS FSRRCSYIAE SDAAVKEKAI QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC TLHDEMLHWF RAVECCVRLL HVRNGNCKYH LGEETFKLAQ TYMDKLSKHG QQANKAALYG ELCALLFAKS HYDEAYKWCI EAMKEITAGL PVKVVVDVLR QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF DNALFHAERA IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ RLLQEAHDLH LSSLQLAKKA FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE MHIKAIQIKE QLLGQEDYEV ALSVGHLASL YNYDMNQYEN AEKLYLRSIA IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL SNWNRLRDRQ YSVTDALEDV STSPQSTEEV VQSFLISQNV EGPSC
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