Lysophosphatidic acid receptor 1 (LPAR1)

About Lysophosphatidic acid receptor 1

Lysophosphatidic acid receptor 1 (LPAR1) is a protein from Homo sapiens identified by UniProt accession Q92633, 364 residues long. MolForge cross-references it against 0 known binders and 332 disease associations.

Target properties

Protein name	Lysophosphatidic acid receptor 1
UniProt accession	Q92633
Gene	LPAR1
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (332)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.50
body height · score 0.46
monocyte count · score 0.46
cortical thickness · score 0.45
central corneal thickness · score 0.44
eosinophil percentage of leukocytes · score 0.42
monocyte percentage of leukocytes · score 0.42
BMI-adjusted waist-hip ratio · score 0.40
neuroimaging measurement · score 0.39
appendicular lean mass · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92633-F1	alphafold	PREDICTED	83.62	—

Amino-acid sequence (364 residues)

MAAISTSIPV ISQPQFTAMN EPQCFYNESI AFFYNRSGKH LATEWNTVSK LVMGLGITVC IFIMLANLLV MVAIYVNRRF HFPIYYLMAN LAAADFFAGL AYFYLMFNTG PNTRRLTVST WLLRQGLIDT SLTASVANLL AIAIERHITV FRMQLHTRMS NRRVVVVIVV IWTMAIVMGA IPSVGWNCIC DIENCSNMAP LYSDSYLVFW AIFNLVTFVV MVVLYAHIFG YVRQRTMRMS RHSSGPRRNR DTMMSLLKTV VIVLGAFIIC WTPGLVLLLL DVCCPQCDVL AYEKFFLLLA EFNSAMNPII YSYRDKEMSA TFRQILCCQR SENPTGPTEG SDRSASSLNH TILAGVHSND HSVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards