GPI-anchor transamidase (PIGK)

About GPI-anchor transamidase

GPI-anchor transamidase (PIGK) is a protein from Homo sapiens identified by UniProt accession Q92643, 395 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	GPI-anchor transamidase
UniProt accession	Q92643
Gene	PIGK
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with hypotonia and cerebellar atrophy, with or without seizures · score 0.73
neurodegenerative disease · score 0.48
chronotype measurement · score 0.24
genetic disorder · score 0.19
circadian rhythm · score 0.17
lysosomal storage disease · score 0.17
sleep duration · score 0.08
excessive daytime sleepiness measurement · score 0.08
insomnia measurement · score 0.08
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92643-F1	alphafold	PREDICTED	85.04	—

Amino-acid sequence (395 residues)

MAVTDSLSRA ATVLATVLLL SFGSVAASHI EDQAEQFFRS GHTNNWAVLV CTSRFWFNYR HVANTLSVYR SVKRLGIPDS HIVLMLADDM ACNPRNPKPA TVFSHKNMEL NVYGDDVEVD YRSYEVTVEN FLRVLTGRIP PSTPRSKRLL SDDRSNILIY MTGHGGNGFL KFQDSEEITN IELADAFEQM WQKRRYNELL FIIDTCQGAS MYERFYSPNI MALASSQVGE DSLSHQPDPA IGVHLMDRYT FYVLEFLEEI NPASQTNMND LFQVCPKSLC VSTPGHRTDL FQRDPKNVLI TDFFGSVRKV EITTETIKLQ QDSEIMESSY KEDQMDEKLM EPLKYAEQLP VAQIIHQKPK LKDWHPPGGF ILGLWALIIM VFFKTYGIKH MKFIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards