Transcription factor IIIA (GTF3A)

About Transcription factor IIIA

Transcription factor IIIA (GTF3A) is a protein from Homo sapiens identified by UniProt accession Q92664, 365 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Transcription factor IIIA
UniProt accession	Q92664
Gene	GTF3A
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
body mass index · score 0.38
lean body mass · score 0.35
fat body mass · score 0.33
body fat percentage · score 0.32
Red cell distribution width · score 0.31
body weight · score 0.30
base metabolic rate measurement · score 0.23
serum alanine aminotransferase measurement · score 0.22
sex hormone-binding globulin measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92664-F1	alphafold	PREDICTED	69.68	—

Amino-acid sequence (365 residues)

MDPPAVVAES VSSLTIADAF IAAGESSAPT PPRPALPRRF ICSFPDCSAN YSKAWKLDAH LCKHTGERPF VCDYEGCGKA FIRDYHLSRH ILTHTGEKPF VCAANGCDQK FNTKSNLKKH FERKHENQQK QYICSFEDCK KTFKKHQQLK IHQCQHTNEP LFKCTQEGCG KHFASPSKLK RHAKAHEGYV CQKGCSFVAK TWTELLKHVR ETHKEEILCE VCRKTFKRKD YLKQHMKTHA PERDVCRCPR EGCGRTYTTV FNLQSHILSF HEESRPFVCE HAGCGKTFAM KQSLTRHAVV HDPDKKKMKL KVKKSREKRS LASHLSGYIP PKRKQGQGLS LCQNGESPNC VEDKMLSTVA VLTLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards