About Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) is a protein
from Homo sapiens identified by UniProt accession
Q92685, 438 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase |
|---|
| UniProt accession | Q92685 |
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| Gene | ALG3 |
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| Organism | Homo sapiens |
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| Length | 438 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- ALG3-congenital disorder of glycosylation · score 0.83
- congenital disorder of glycosylation · score 0.56
- genetic disorder · score 0.41
- congenital disorder of glycosylation type I · score 0.37
- neurodegenerative disease · score 0.30
- Intellectual disability · score 0.29
- cortical thickness · score 0.13
- Microcephaly · score 0.12
- Seizure · score 0.12
- mathematical ability · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92685-F1 | alphafold | PREDICTED | 88.98 | — |
Amino-acid sequence (438 residues)
MAAGLRKRGR SGSAAQAEGL CKQWLQRAWQ ERRLLLREPR YTLLVAACLC LAEVGITFWV IHRVAYTEID WKAYMAEVEG VINGTYDYTQ LQGDTGPLVY PAGFVYIFMG LYYATSRGTD IRMAQNIFAV LYLATLLLVF LIYHQTCKVP PFVFFFMCCA SYRVHSIFVL RLFNDPVAMV LLFLSINLLL AQRWGWGCCF FSLAVSVKMN VLLFAPGLLF LLLTQFGFRG ALPKLGICAG LQVVLGLPFL LENPSGYLSR SFDLGRQFLF HWTVNWRFLP EALFLHRAFH LALLTAHLTL LLLFALCRWH RTGESILSLL RDPSKRKVPP QPLTPNQIVS TLFTSNFIGI CFSRSLHYQF YVWYFHTLPY LLWAMPARWL THLLRLLVLG LIELSWNTYP STSCSSAALH ICHAVILLQL WLGPQPFPKS TQHSKKAH
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