Neurogranin (NRGN)

About Neurogranin

Neurogranin (NRGN) is a protein from Homo sapiens identified by UniProt accession Q92686, 78 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.

Target properties

Protein name	Neurogranin
UniProt accession	Q92686
Gene	NRGN
Organism	Homo sapiens
Length	78 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (209)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
schizophrenia · score 0.30
autism spectrum disorder · score 0.22
attention deficit hyperactivity disorder · score 0.22
bipolar disorder · score 0.18
unipolar depression · score 0.18
obsessive-compulsive disorder · score 0.18
anorexia nervosa · score 0.18
Tourette syndrome · score 0.18
intelligence · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92686-F1	alphafold	PREDICTED	68.14	—

Amino-acid sequence (78 residues)

MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE RGRKGPGPGG PGGAGVARGG AGGGPSGD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards