About Geranylgeranyl transferase type-2 subunit alpha
Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) is a protein
from Homo sapiens identified by UniProt accession
Q92696, 567 residues long.
MolForge cross-references it against 0 known binders and
125 disease associations.
Target properties
| Protein name | Geranylgeranyl transferase type-2 subunit alpha |
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| UniProt accession | Q92696 |
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| Gene | RABGGTA |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (125)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- neuroinflammatory disorder · score 0.32
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.25
- gastric adenocarcinoma · score 0.23
- squamous cell lung carcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- endometrial cancer · score 0.23
- urinary bladder cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92696-F1 | alphafold | PREDICTED | 93.65 | — |
Amino-acid sequence (567 residues)
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL RVNPKSYGTW HHRCWLLGRL PEPNWTRELE LCARFLEVDE RNFHCWDYRR FVATQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY EKETLQYFQT LKAVDPMRAT YLDDLRSKFL LENSVLKMEY AEVRVLHLAH KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP ALAALRCLEV LQASDNAIES LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL QGNPLCQAVG ILEQLAELLP SVSSVLT
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