About Rho-related GTP-binding protein Rho6
Rho-related GTP-binding protein Rho6 (RND1) is a protein
from Homo sapiens identified by UniProt accession
Q92730, 232 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Rho-related GTP-binding protein Rho6 |
|---|
| UniProt accession | Q92730 |
|---|
| Gene | RND1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 232 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.21
- self reported educational attainment · score 0.20
- cutaneous melanoma · score 0.11
- hepatocellular carcinoma · score 0.08
- glioblastoma · score 0.08
- glioblastoma multiforme · score 0.08
- breast carcinoma · score 0.05
- neoplasm · score 0.05
- appendicular lean mass · score 0.05
- bacterial disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92730-F1 | alphafold | PREDICTED | 85.16 | — |
Amino-acid sequence (232 residues)
MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY TACLETEEQR VELSLWDTSG SPYYDNVRPL CYSDSDAVLL CFDISRPETV DSALKKWRTE ILDYCPSTRV LLIGCKTDLR TDLSTLMELS HQKQAPISYE QGCAIAKQLG AEIYLEGSAF TSEKSIHSIF RTASMLCLNK PSPLPQKSPV RSLSKRLLHL PSRSELISST FKKEKAKSCS IM
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