Proline-rich protein PRCC (PRCC)

About Proline-rich protein PRCC

Proline-rich protein PRCC (PRCC) is a protein from Homo sapiens identified by UniProt accession Q92733, 491 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Proline-rich protein PRCC
UniProt accession	Q92733
Gene	PRCC
Organism	Homo sapiens
Length	491 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
renal carcinoma · score 0.37
papillary renal cell carcinoma · score 0.21
hepatocellular carcinoma · score 0.20
Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions · score 0.20
PEComa · score 0.19
melanoma · score 0.19
kidney neoplasm · score 0.19
head and neck squamous cell carcinoma · score 0.19
acute myeloid leukemia · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92733-F1	alphafold	PREDICTED	59.14	—

Amino-acid sequence (491 residues)

MSLVAYASSD ESEPDEAEPE PEEEEAVAPT SGPALGGLFA SLPAPKGPAL LPPPPQMLAP AFPPPLLLPP PTGDPRLQPP PPLPFGLGGF PPPPGVSPAE AAGVGEGLGL GLPSPRGPGL NLPPPIGGAG PPLGLPKPKK RKEPVKIAAP ELHKGDSDSE EDEPTKKKTI LQGSSEGTGL SALLPQPKNL TVKETNRLLL PHAFSRKPSD GSPDTKPSRL ASKTKTSSLA PVVGTTTTTP SPSAIKAAAK SAALQVTKQI TQEEDDSDEE VAPENFFSLP EKAEPPGVEP YPYPIPTVPE ELPPGTEPEP AFQDDAANAP LEFKMAAGSS GAPWMPKPGD DYSYNQFSTY GDANAAGAYY QDYYSGGYYP AQDPALVPPQ EIAPDASFID DEAFKRLQGK RNRGREEINF VEIKGDDQLS GAQQWMTKSL TEEKTMKSFS KKKGEQPTGQ QRRKHQITYL IHQAKERELE LKNTWSENKL SRRQTQAKYG F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards