Protein TFG (TFG)

About Protein TFG

Protein TFG (TFG) is a protein from Homo sapiens identified by UniProt accession Q92734, 400 residues long. MolForge cross-references it against 0 known binders and 195 disease associations.

Target properties

Protein name	Protein TFG
UniProt accession	Q92734
Gene	TFG
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (195)

Diseases linked to this target (Open Targets).

Autosomal recessive spastic paraplegia type 57 · score 0.77
hereditary motor and sensory neuropathy, Okinawa type · score 0.73
hereditary spastic paraplegia 57 · score 0.68
cancer · score 0.57
neurodegenerative disease · score 0.55
genetic disorder · score 0.41
anaplastic large cell lymphoma · score 0.37
papillary thyroid carcinoma · score 0.37
Follicular Variant Thyroid Gland Papillary Carcinoma · score 0.37
Benign Thyroid Gland Neoplasm · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92734-F1	alphafold	PREDICTED	59.50	—

Amino-acid sequence (400 residues)

MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL DSLEPPGEPG PSTNIPENDT VDGREEKSAS DSSGKQSTQV MAASMSAFDP LKNQDEINKN VMSAFGLTDD QVSGPPSAPA EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE GQMYQQYQQQ AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA PSQPGAYQPR PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards