About Serine protease HTRA1
Serine protease HTRA1 (HTRA1) is a protein
from Homo sapiens identified by UniProt accession
Q92743, 480 residues long.
MolForge cross-references it against 0 known binders and
350 disease associations.
Target properties
| Protein name | Serine protease HTRA1 |
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| UniProt accession | Q92743 |
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| Gene | HTRA1 |
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| Organism | Homo sapiens |
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| Length | 480 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (350)
Diseases linked to this target (Open Targets).
- cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 · score 0.75
- CARASIL syndrome · score 0.72
- CARASIL · score 0.71
- vital capacity · score 0.59
- body height · score 0.58
- age related macular degeneration 7 · score 0.55
- age-related macular degeneration · score 0.52
- HTRA1-related autosomal dominant cerebral small vessel disease · score 0.45
- Cognitive impairment · score 0.43
- HTRA1-related cerebral small vessel disease · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92743-F1 | alphafold | PREDICTED | 83.27 | — |
Amino-acid sequence (480 residues)
MQIPRAALLP LLLLLLAAPA SAQLSRAGRS APLAAGCPDR CEPARCPPQP EHCEGGRARD ACGCCEVCGA PEGAACGLQE GPCGEGLQCV VPFGVPASAT VRRRAQAGLC VCASSEPVCG SDANTYANLC QLRAASRRSE RLHRPPVIVL QRGACGQGQE DPNSLRHKYN FIADVVEKIA PAVVHIELFR KLPFSKREVP VASGSGFIVS EDGLIVTNAH VVTNKHRVKV ELKNGATYEA KIKDVDEKAD IALIKIDHQG KLPVLLLGRS SELRPGEFVV AIGSPFSLQN TVTTGIVSTT QRGGKELGLR NSDMDYIQTD AIINYGNSGG PLVNLDGEVI GINTLKVTAG ISFAIPSDKI KKFLTESHDR QAKGKAITKK KYIGIRMMSL TSSKAKELKD RHRDFPDVIS GAYIIEVIPD TPAEAGGLKE NDVIISINGQ SVVSANDVSD VIKRESTLNM VVRRGNEDIM ITVIPEEIDP
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