Actin-related protein 2/3 complex subunit 1A (ARPC1A)

About Actin-related protein 2/3 complex subunit 1A

Actin-related protein 2/3 complex subunit 1A (ARPC1A) is a protein from Homo sapiens identified by UniProt accession Q92747, 370 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Actin-related protein 2/3 complex subunit 1A
UniProt accession	Q92747
Gene	ARPC1A
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
cutaneous Leishmaniasis · score 0.37
pancreatic adenocarcinoma · score 0.21
lymphocyte count · score 0.19
alcohol consumption measurement · score 0.19
endometrial cancer · score 0.18
breast adenocarcinoma · score 0.18
hormone measurement · score 0.17
serum metabolite measurement · score 0.15
alcohol use disorder measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92747-F1	alphafold	PREDICTED	92.23	—

Amino-acid sequence (370 residues)

MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS TLKTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL ESSIQGLRIM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards