Thyroid hormone-inducible hepatic protein (THRSP)

About Thyroid hormone-inducible hepatic protein

Thyroid hormone-inducible hepatic protein (THRSP) is a protein from Homo sapiens identified by UniProt accession Q92748, 146 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Thyroid hormone-inducible hepatic protein
UniProt accession	Q92748
Gene	THRSP
Organism	Homo sapiens
Length	146 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.10
attention deficit hyperactivity disorder · score 0.07
psoriasis · score 0.04
Åland Islands eye disease · score 0.04
papillary thyroid carcinoma · score 0.03
non-small cell lung carcinoma · score 0.03
vulvar intraepithelial neoplasia · score 0.03
Acute hepatic failure · score 0.02
neoplasm · score 0.02
body height · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92748-F1	alphafold	PREDICTED	74.85	—

Amino-acid sequence (146 residues)

MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ AEAPDLYTYF TMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED ESASGELDLE AQFHLHFSSL HHILMHLTEK AQEVTRKYQE MTGQVW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards