About Transcription initiation factor TFIID subunit 4B
Transcription initiation factor TFIID subunit 4B (TAF4B) is a protein
from Homo sapiens identified by UniProt accession
Q92750, 862 residues long.
MolForge cross-references it against 0 known binders and
254 disease associations.
Target properties
| Protein name | Transcription initiation factor TFIID subunit 4B |
|---|
| UniProt accession | Q92750 |
|---|
| Gene | TAF4B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 862 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (254)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.58
- spermatogenic failure 13 · score 0.46
- erythrocyte count · score 0.42
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.39
- hematocrit · score 0.37
- red blood cell density measurement · score 0.37
- venous thromboembolism · score 0.30
- mean reticulocyte volume · score 0.26
- low grade glioma · score 0.25
- glioblastoma multiforme · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92750-F1 | alphafold | PREDICTED | 54.58 | — |
Amino-acid sequence (862 residues)
MPAGLTEPAG AAPPAAVSAS GTVTMAPAGA LPVRVESTPV ALGAVTKAPV SVCVEPTASQ PLRSPVGTLV TKVAPVSAPP KVSSGPRLPA PQIVAVKAPN TTTIQFPANL QLPPGTVLIK SNSGPLMLVS PQQTVTRAET TSNITSRPAV PANPQTVKIC TVPNSSSQLI KKVAVTPVKK LAQIGTTVVT TVPKPSSVQS VAVPTSVVTV TPGKPLNTVT TLKPSSLGAS STPSNEPNLK AENSAAVQIN LSPTMLENVK KCKNFLAMLI KLACSGSQSP EMGQNVKKLV EQLLDAKIEA EEFTRKLYVE LKSSPQPHLV PFLKKSVVAL RQLLPNSQSF IQQCVQQTSS DMVIATCTTT VTTSPVVTTT VSSSQSEKSI IVSGATAPRT VSVQTLNPLA GPVGAKAGVV TLHSVGPTAA TGGTTAGTGL LQTSKPLVTS VANTVTTVSL QPEKPVVSGT AVTLSLPAVT FGETSGAAIC LPSVKPVVSS AGTTSDKPVI GTPVQIKLAQ PGPVLSQPAG IPQAVQVKQL VVQQPSGGNE KQVTTISHSS TLTIQKCGQK TMPVNTIIPT SQFPPASILK QITLPGNKIL SLQASPTQKN RIKENVTSCF RDEDDINDVT SMAGVNLNEE NACILATNSE LVGTLIQSCK DEPFLFIGAL QKRILDIGKK HDITELNSDA VNLISQATQE RLRGLLEKLT AIAQHRMTTY KASENYILCS DTRSQLKFLE KLDQLEKQRK DLEEREMLLK AAKSRSNKED PEQLRLKQKA KELQQLELAQ IQHRDANLTA LAAIGPRKKR PLESGIEGLK DNLLASGTSS LTATKQLHRP RITRICLRDL IFCMEQEREM KYSRALYLAL LK
Explore Transcription initiation factor TFIID subunit 4B with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets