Nuclear receptor ROR-beta (RORB)

About Nuclear receptor ROR-beta

Nuclear receptor ROR-beta (RORB) is a protein from Homo sapiens identified by UniProt accession Q92753, 470 residues long. MolForge cross-references it against 0 known binders and 234 disease associations.

Target properties

Protein name	Nuclear receptor ROR-beta
UniProt accession	Q92753
Gene	RORB
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (234)

Diseases linked to this target (Open Targets).

generalised epilepsy · score 0.73
neurodegenerative disease · score 0.55
genetic disorder · score 0.49
testosterone measurement · score 0.47
body height · score 0.43
reticulocyte count · score 0.43
age at menarche · score 0.42
refractive error measurement · score 0.42
Abnormality of refraction · score 0.41
refractive error · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92753-F1	alphafold	PREDICTED	78.80	—

Amino-acid sequence (470 residues)

MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNNETSG TYANGHVIDL PKSEGYYNVD SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY TMEELHQLAW QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPEIVN TLFPPLYKEL FNPDCATGCK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards