Transcription factor AP-2 gamma (TFAP2C)

About Transcription factor AP-2 gamma

Transcription factor AP-2 gamma (TFAP2C) is a protein from Homo sapiens identified by UniProt accession Q92754, 450 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.

Target properties

Protein name	Transcription factor AP-2 gamma
UniProt accession	Q92754
Gene	TFAP2C
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (119)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
FEV/FVC ratio · score 0.35
blood urea nitrogen measurement · score 0.31
hair shape measurement · score 0.29
systolic blood pressure · score 0.28
smoking status measurement · score 0.28
glioblastoma multiforme · score 0.27
snoring measurement · score 0.27
hair color · score 0.27
endometrial cancer · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92754-F1	alphafold	PREDICTED	66.28	—

Amino-acid sequence (450 residues)

MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards