General transcription factor IIH subunit 4 (GTF2H4)

About General transcription factor IIH subunit 4

General transcription factor IIH subunit 4 (GTF2H4) is a protein from Homo sapiens identified by UniProt accession Q92759, 462 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	General transcription factor IIH subunit 4
UniProt accession	Q92759
Gene	GTF2H4
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

HIV infection · score 0.59
endometrial cancer · score 0.24
glioblastoma multiforme · score 0.23
squamous cell lung carcinoma · score 0.18
ovarian cancer · score 0.18
complement C4 measurement · score 0.11
QRS duration · score 0.08
age-related macular degeneration · score 0.05
BMI-adjusted hip circumference · score 0.05
BMI-adjusted waist circumference · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92759-F1	alphafold	PREDICTED	85.23	—

Amino-acid sequence (462 residues)

MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS LAKNWVMRML FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL LPGGLQGLIL NPIFRQNLRI ALLGGGKAWS DDTSQLGPDK HARDVPSLDK YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP GEPPCITSAG FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGAGGT VHQPGFIVVE TNYRLYAYTE SELQIALIAL FSEMLYRFPN MVVAQVTRES VQQAIASGIT AQQIIHFLRT RAHPVMLKQT PVLPPTITDQ IRLWELERDR LRFTEGVLYN QFLSQVDFEL LLAHARELGV LVFENSAKRL MVVTPAGHSD VKRFWKRQKH SS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards