Keratin, type I cuticular Ha5 (KRT35)

About Keratin, type I cuticular Ha5

Keratin, type I cuticular Ha5 (KRT35) is a protein from Homo sapiens identified by UniProt accession Q92764, 455 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Keratin, type I cuticular Ha5
UniProt accession	Q92764
Gene	KRT35
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
clear cell renal carcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.18
glioblastoma multiforme · score 0.18
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
esophageal cancer · score 0.14
neuroblastoma · score 0.13
low grade glioma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92764-F1	alphafold	PREDICTED	74.51	—

Amino-acid sequence (455 residues)

MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards