Secreted frizzled-related protein 3 (FRZB)

About Secreted frizzled-related protein 3

Secreted frizzled-related protein 3 (FRZB) is a protein from Homo sapiens identified by UniProt accession Q92765, 325 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.

Target properties

Protein name	Secreted frizzled-related protein 3
UniProt accession	Q92765
Gene	FRZB
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (265)

Diseases linked to this target (Open Targets).

body height · score 0.47
blood protein measurement · score 0.44
heel bone mineral density · score 0.43
cortical surface area measurement · score 0.38
Secreted frizzled-related protein 3 measurement · score 0.31
self reported educational attainment · score 0.31
brain measurement · score 0.30
appendicular lean mass · score 0.29
sitting height measurement · score 0.15
metabolite measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92765-F1	alphafold	PREDICTED	79.90	—

Amino-acid sequence (325 residues)

MVCGSPGGML LLRAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM TKMPNHLHHS TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE PILIKYRHSW PENLACEELP VYDRGVCISP EAIVTADGAD FPMDSSNGNC RGASSERCKC KPIRATQKTY FRNNYNYVIR AKVKEIKTKC HDVTAVVEVK EILKSSLVNI PRDTVNLYTS SGCLCPPLNV NEEYIIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLSK SDSSNSDSTQ SQKSGRNSNP RQARN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards