About Ras-responsive element-binding protein 1
Ras-responsive element-binding protein 1 (RREB1) is a protein
from Homo sapiens identified by UniProt accession
Q92766, 1687 residues long.
MolForge cross-references it against 0 known binders and
518 disease associations.
Target properties
| Protein name | Ras-responsive element-binding protein 1 |
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| UniProt accession | Q92766 |
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| Gene | RREB1 |
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| Organism | Homo sapiens |
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| Length | 1687 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (518)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.50
- neutrophil count · score 0.50
- BMI-adjusted waist-hip ratio · score 0.50
- urate measurement · score 0.49
- hemoglobin measurement · score 0.49
- lymphocyte count · score 0.49
- reticulocyte count · score 0.49
- leukocyte count · score 0.49
- monocyte count · score 0.48
- heel bone mineral density · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92766-F1 | alphafold | PREDICTED | 47.36 | — |
Amino-acid sequence (1687 residues)
MTSSSPAGLE GSDLSSINTM MSAVMSVGKV TENGGSPQGI KSPSKPPGPN RIGRRNQETK EEKSSYNCPL CEKICTTQHQ LTMHIRQHNT DTGGADHSCS ICGKSLSSAS SLDRHMLVHS GERPYKCTVC GQSFTTNGNM HRHMKIHEKD PNSATATAPP SPLKRRRLSS KRKLSHDAES EREDPAPAKK MVEDGQSGDL EKKADEVFHC PVCFKEFVCK YGLETHMETH SDNPLRCDIC CVTFRTHRGL LRHNALVHKQ LPRDAMGRPF IQNNPSIPAG FHDLGFTDFS CRKFPRISQA WCETNLRRCI SEQHRFVCDT CDKAFPMLCS LALHKQTHVA ADQGQEKPQA TPLPGDALDQ KGFLALLGLQ HTKDVRPAPA EEPLPDDNQA IQLQTLKCQL PQDPGCTNLL SLSPFEAASL GGSLTVLPAT KDSIKHLSLQ PFQKGFIIQP DSSIVVKPIS GESAIELADI QQILKMAASA PPQISLPPFS KAPAAPLQAI FKHMPPLKPK PLVTPRTVVA TSTPPPLINA QQASPGCISP SLPPPPLKLL KGSVEAASNA HLLQSKSGTQ PHAATRLSLQ QPRAELPGQP EMKTQLEQDS IIEALLPLSM EAKIKQEITE GELKAFMTAP GGKKTPAMRK VLYPCRFCNQ VFAFSGVLRA HVRSHLGISP YQCNICDYIA ADKAALIRHL RTHSGERPYI CKICHYPFTV KANCERHLRK KHLKATRKDI EKNIEYVSSS AAELVDAFCA PDTVCRLCGE DLKHYRALRI HMRTHCGRGL GGGHKGRKPF ECKECSAAFA AKRNCIHHIL KQHLHVPEQD IESYVLAADG LGPAEAPAAE ASGRGEDSGC AALGDCKPLT AFLEPQNGFL HRGPTQPPPP HVSIKLEPAS SFAVDFNEPL DFSQKGLALV QVKQENISFL SPSSLVPYDC SMEPIDLSIP KNFRKGDKDL ATPSEAKKPE EEAGSSEQPS PCPAPGPSLP VTLGPSGILE SPMAPAPAAT PEPPAQPLQG PVQLAVPIYS SALVSSPPLV GSSALLSGTA LLRPLRPKPP LLLPKPPVTE ELPPLASIAQ IISSVSSAPT LLKTKVADPG PASTGSNTTA SDSLGGSVPK AATTATPAAT TSPKESSEPP APASSPEAAS PTEQGPAGTS KKRGRKRGMR SRPRANSGGV DLDSSGEFAS IEKMLATTDT NKFSPFLQTA EDNTQDEVAG APADHHGPSD EEQGSPPEDK LLRAKRNSYT NCLQKITCPH CPRVFPWASS LQRHMLTHTD SQSDAETAAA AGEVLDLTSR DREQPSEGAT ELRQVAGDAP VEQATAETAS PVHREEHGRG ESHEPEEEHG TEESTGDADG AEEDASSNQS LDLDFATKLM DFKLAEGDGE AGAGGAASQE QKLACDTCGK SFKFLGTLSR HRKAHGRQEP KDEKGDGAST AEEGPQPAPE QEEKPPETPA EVVESAPGAG EAPAEKLAEE TEGPSDGESA AEKRSSEKSD DDKKPKTDSP KSVASKADKR KKVCSVCNKR FWSLQDLTRH MRSHTGERPY KCQTCERTFT LKHSLVRHQR IHQKARHAKH HGKDSDKEER GEEDSENEST HSGNNAVSEN EAELAPNASN HMAVTRSRKE GLASATKDCS HREEKVTAGW PSEPGQGDLN PESPAALGQD LLEPRSKRPA HPILATADGA SQLVGME
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