Histone deacetylase 2 (HDAC2)

About Histone deacetylase 2

Histone deacetylase 2 (HDAC2) is a protein from Homo sapiens identified by UniProt accession Q92769, 488 residues long. MolForge cross-references it against 0 known binders and 631 disease associations.

Target properties

Protein name	Histone deacetylase 2
UniProt accession	Q92769
Gene	HDAC2
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (631)

Diseases linked to this target (Open Targets).

neoplasm · score 0.57
multiple myeloma · score 0.56
neurodegenerative disease · score 0.52
unspecified peripheral T-cell lymphoma · score 0.52
Cutaneous T-cell lymphoma · score 0.51
T-cell non-Hodgkin lymphoma · score 0.50
graft versus host disease · score 0.39
primary myelofibrosis · score 0.38
lymphoma · score 0.38
acute myeloid leukemia · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q92769-F1	alphafold	PREDICTED	85.58	—

Amino-acid sequence (488 residues)

MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT KSEQLSNP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards