About Cyclin-dependent kinase-like 2
Cyclin-dependent kinase-like 2 (CDKL2) is a protein
from Homo sapiens identified by UniProt accession
Q92772, 493 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase-like 2 |
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| UniProt accession | Q92772 |
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| Gene | CDKL2 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (40)
Diseases linked to this target (Open Targets).
- Testicular Germ Cell Tumor · score 0.29
- type 2 diabetes mellitus · score 0.23
- Red cell distribution width · score 0.14
- neurodegenerative disease · score 0.13
- high density lipoprotein cholesterol measurement · score 0.09
- gonorrhea · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
- neoplasm · score 0.06
- serum alanine aminotransferase measurement · score 0.05
- autosomal recessive hypophosphatemic rickets · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q92772-F1 | alphafold | PREDICTED | 70.30 | — |
Amino-acid sequence (493 residues)
MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL PEIKEREPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD YKLFKIKGSK IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV SVDHTRNPSV AIPPLTHNLS AVAPSINSGM GTETIPIQGY RVDEKTKKCS IPFVKPNRHS PSGIYNINVT TLVSGPPLSD DSGADLPQME HQH
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